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390 MMP FRET Substrate I

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Catalogue number:
ANA27076
Size:
1 mg
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A fluorogenic substrate that is best cleaved by MMP-7, 8, 9 and 13. The highly fluorescent Mca moiety is efficiently quenched by energy transfer to the Dnp group. The punctuated metallo proteinase (PUMP, EC 3.4.24.23) cleaves the substrate at the Gly-Leu bond with a 190-fold increase in fluorescence (Abs/Em = 325/393 nm). In human matrix metalloproteinases assays, this substrate is about 50 to 100 times more sensitive than the generic MMP substrate, Dnp-PLGLWAr-NH2 (Cat# 27074).

Product Type:

Proteins & Peptides

Storage Temp:

-20°C

Compound Purity:

Peak Area by HPLC ≥95%

Molecular Weight:

1093.2

Reference:

Ref: Knight, CG. et al. FEBS Lett. 296, 263 (1992); Netzel-Arnett, S. et al. Anal. Biochem. 195, 86 (1991).

UNSPSC Code:

12352202

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