Auranofin

A gold-thiol complex with diverse biological activities; inhibits thioredoxin reductase (IC50 = 0.2 µM), increases oxidation of mitochondrial PRDX3, and induces apoptosis in Jurkat T cells; reduces the production of IL-6 and activation of JAK1 and JAK2, as well as inhibits nuclear translocation of NF-kB, in primary human synoviocytes; active against P. falciparum and S. mansoni in vitro from 1-10 µM; reduces the number of PBMCs containing viral DNA and delays viral rebound in macaques infected with the mac251 strain of SIV at 2 mg/kg per day; synergizes with BSO to decrease GPX4 levels, increase intracellular accumulation of ROS, and induce ferroptosis in Huh7 and HepG2 hepatocellular carcinoma cells at 0.5 µM