CAL-101
Catalogue number:
CAY15279-5 mg
Supplier:
Size:
5 mg
Product is available in:
£47.00
Estimated delivery Thu 11 Jun
Shipping is calculated in checkout
Shipping is calculated in checkout
This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
870281-82-6
Purity:
≥98%
Formulation:
A crystalline solid
Molecular Formula:
C22H18FN7O
Molecular Weight:
415.4
Alternative Names:
5-
Product Description:
A cell permeable inhibitor of the PI3K catalytic subunit p110δ (IC50 = 2.5 nM) that demonstrates 40- to 300-fold selectivity against other PI3K class I enzymes (IC50s = 820, 565, and 89 nM for p110α, β, and γ, respectively); blocks constitutive PI3K signaling in malignant B-cell lines and primary patient tumor cells, resulting in decreased phosphorylation of Akt and other downstream effectors, an increase in poly(ADP-ribose) polymerase and apoptosis
