ABT-263
Catalogue number:
CAY11500-1 mg
Supplier:
Size:
1 mg
Product is available in:
£37.00
Estimated delivery Mon 13 Apr
Shipping is calculated in checkout
Shipping is calculated in checkout
This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
923564-51-6
Purity:
≥98%
Formulation:
A crystalline solid
Molecular Formula:
C47H55ClF3N5O6S3
Molecular Weight:
974.6
Alternative Names:
4-[4-[[2-(4-chlorophenyl)-5,5-dimethyl-1-cyclohexen-1-yl]methyl]-1-piperazinyl]-n-[[4-[[(1r)-3-(4-morpholinyl)-1-[(phenylthio)methyl]propyl]amino]-3-[(trifluoromethyl)sulfonyl]phenyl]sulfonyl]-benzamide, a-855071, navitoclax
Product Description:
An inhibitor of Bcl-2 family proteins (Kis = is = 550 and 354 nM, respectively); cytotoxic in a panel of SCLC, leukemia, and lymphoma cell lines (mean EC50 = 1 µM); induces apoptosis in influenza A-infected retinal pigment epithelial cells (EC50 = 0.08 µM); induces tumor regression in NCI H146 SCLC and RS4;11 ALL mouse xenograft models at 100 mg/kg
