Temozolomide
Catalogue number:
CAY14163-50 mg
Supplier:
Size:
50 mg
Product is available in:
£152.00
Estimated delivery Wed 12 Nov
Shipping is calculated in checkout
Shipping is calculated in checkout
This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
85622-93-1
Alternative Names:
3,4-dihydro-3-methyl-4-oxo-imidazo[5,1-d]-1,2,3,5-tetrazine-8-carboxamide, ccrg 81045, mb 39831, methazolastone, nsc 362856, tmz
Product Description:
A prodrug form of MTIC; selectively cytotoxic to MGMT-deficient U87 and D54 cells over MGMT-expressing T98G and U3054MG cells (IC50s = 51, 12, 660, and 370 µM, respectively); increases survival in a Br23c glioblastoma orthotopic mouse xenograft model at 15 mg/kg; decreases tumor volume and increases the number of tumor-infiltrating CD4+ and CD8+ T cells in a GL261 murine glioma model in combination with anti-CD47
