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Gastrin-1, human

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Catalogue number:
ANA20750
Size:
1 mg
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Gastrin-1 is also referred to as Gastrin-17 or “Little Gastrin.” Secretion of gastrin is induced by food intake and causes the release of gastric acid in the stomach. Secreted by the G cells in the gastric mucosa, it is one of the major bioactive forms of gastrin found in tissue and plasma (the other bioactive form is Gastrin-34 or Big Gastrin - Cat# AS-20747). Both Gastrin-17 and Gastrin-34 are carboxy-amidated and partially tyrosine sulfated. Binding of Gastrin to the CCK2/gastrin receptor requires carboxy-amidation, however sulfation is not necessary for binding to the receptor. Binding of Gastrin to the CCK2/Gastrin receptors on parietal cells of the stomach causes them to secrete hydrochloric acid (HCl) and stimulates lectin-like protein Reg expression via activation of PKC and RhoA. Gastrin also plays a role in release of Histamine and Pepsinogen.

Product Type:

Proteins & Peptides

Storage Temp:

-20°C

Compound Purity:

Peak Area by HPLC ≥95%

Molecular Weight:

2098.2

Reference:

Choudhury, A. et al. Hoppe-Seylers Z Physiol Chem 361, 1719 (1980)Niederle, B. Wien Klin Wochenschr 119, 561 (2007), doi: 10.1007/s00508-007-0897-x.O’Connor A. et. al. Digestive Dis 32, 186 (2014), doi: 10.1159/000357848Dockray, G. et.al. Pflügers Archiv 449,344 (2005)Bundgaard, JR et al. J Biol Chem 272, 21700 (1997), doi: 10.1074/jbc.272.35.21700Yakabi, K. et al. World J Gastroenterol 14, 6334 (2008), doi: 10.3748/wjg.14.6334

UNSPSC Code:

12352202

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