I-CBP112 (hydrochloride)
Catalogue number:
CAY14468-1 mg
Supplier:
Size:
1 mg
Product is available in:
£62.00
Estimated delivery Tue 13 Jan
Shipping is calculated in checkout
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This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
2147701-33-3
Purity:
≥90%
Formulation:
A crystalline solid
Molecular Formula:
C27H36N2O5 • HCl
Molecular Weight:
505.1
Alternative Names:
1-[7-(3,4-
- MSDS: View or download
Product Description:
A p300 and CBP inhibitor; binds to the p300 and CBP bromodomains (Kds = 167 and 151 nM, respectively); selective for p300 and CBP over BRD4, as well as a panel of 104 nuclear receptors and ion channels and a panel of 32 enzymes at 10 µM; displaces acetylated histones from CBP in a cell-free assay (IC50 = 170 nM); reduces colony formation and increases differentiation of primary murine leukemic blasts and delays disease initiation following leukemic blast transplantation into sub-lethally irradiated mice when used at concentrations of 5 and 10 µM
