Glyburide (potassium salt)
Catalogue number:
CAY15009-5 g
Supplier:
Size:
5 g
Product is available in:
£135.00
Estimated delivery Thu 6 Aug
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This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
52169-36-5
Purity:
≥98%
Formulation:
A crystalline solid
Molecular Formula:
C23H27ClN3O5S • K
Molecular Weight:
532.0947
Alternative Names:
5-chloro-n-[2-[4-[[[(cyclohexylamino)carbonyl]amino]sulfonyl]phenyl]ethyl]-2-methoxy-benzamide, monopotassium salt, glibenclamide
- MSDS: View or download
Product Description:
A sulfonylurea; an inhibitor of SUR1 linked to Kir6.2 (IC50 = 4.3 nM); binds to RINm5F microsomes (Kd = 0.3 nM); inhibits 86Rb+ efflux from intact RINm5 cells (K0.5 = 0.06 nM); reduces blood glucose levels and increases the activity of hepatic GST and G6PDH in an STZ-induced rat model of diabetes at 5 mg/kg; inhibits ATP-induced increases in caspase-1 activation and IL-1β and IL-18 secretion in a concentration-dependent manner in LPS-primed BMDMs; reduces lesion growth in mice infected with L. mexicana at 80 mg/ml
