Glyburide (potassium salt)
Catalogue number:
CAY15009-5 g
Supplier:
Size:
5 g
Product is available in:
£122.00
Estimated delivery Thu 30 Oct
Shipping is calculated in checkout
Shipping is calculated in checkout
This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
52169-36-5
Alternative Names:
5-chloro-n-[2-[4-[[[(cyclohexylamino)carbonyl]amino]sulfonyl]phenyl]ethyl]-2-methoxy-benzamide, monopotassium salt, glibenclamide
Product Description:
A sulfonylurea; an inhibitor of SUR1 linked to Kir6.2 (IC50 = 4.3 nM); binds to RINm5F microsomes (Kd = 0.3 nM); inhibits 86Rb+ efflux from intact RINm5 cells (K0.5 = 0.06 nM); reduces blood glucose levels and increases the activity of hepatic GST and G6PDH in an STZ-induced rat model of diabetes at 5 mg/kg; inhibits ATP-induced increases in caspase-1 activation and IL-1β and IL-18 secretion in a concentration-dependent manner in LPS-primed BMDMs; reduces lesion growth in mice infected with L. mexicana at 80 mg/ml
