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Gossypol

Supplier:
Catalogue number:
g5874-250 mg
Size:
250 mg
Product is available in:
  • UK
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£291.00 Estimated delivery Tue 5 Oct
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Polyphenol found in Gossypium; calcineurin and PKC inhibitor.

Product Type:

Biochemicals

CAS Number:

303-45-7

Alternative Names:

2,2'-bis(8-Formyl-1,6,7-trihydroxy-5-isopropyl-3-methylnaphthalene)

Storage Temp:

4°C

Compound Purity:

≥98%

Molecular Weight:

518.55

Reference:

Jang GH, Lee M. BH3-mimetic gossypol-induced autophagic cell death in mutant BRAF melanoma cells with high expression of p21Cip¹.). Life Sci. 2014 Apr 25;102(1):41-8. PMID: 24625733. Song B, Huang G, Tong C, et al. Gossypol suppresses mouse T lymphocytes via inhibition of NFκB, NFAT and AP-1 pathways. Immunopharmacol Immunotoxicol. 2013 Oct;35(5):615-21. PMID: 23981004. Lin J, Wu Y, Yang D, et al. Induction of apoptosis and antitumor effects of a small molecule inhibitor of Bcl-2 and Bcl-xl, gossypol acetate, in multiple myeloma in vitro and in vivo. Oncol Rep. 2013 Aug;30(2):731-8. PMID: 23708869. Yang J, Chen G, Li LL, et al. Synthesis and anti-H5N1 activity of chiral gossypol derivatives and its analogs implicated by a viral entry blocking mechanism. Bioorg Med Chem Lett. 2013 May 1;23(9):2619-23. PMID: 23538114. Coutinho EM. Gossypol: a contraceptive for men. Contraception. 2002 Apr;65(4):259-63. PMID: 12020773. Polsky B, Segal SJ, Baron PA, et al. Inactivation of human immunodeficiency virus in vitro by gossypol. Contraception. 1989 Jun;39(6):579-87. PMID: 2473865. Volate SR, Kawasaki BT, Hurt EM, et al. Gossypol induces apoptosis by activating p53 in prostate cancer cells and prostate tumor-initiating cells. Mol Cancer Ther. 2010 Feb;9(2):461-470. PMID: 20124455.

Structure:

C30H30O8

Formula:

C30H30O8

UNSPSC Code:

12352200

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