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Gossypol Acetic Acid

Supplier:
Catalogue number:
g5875-250 mg
Size:
250 mg
Product is available in:
  • UK
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£165.00 Estimated delivery Tue 28 Sep
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Bcl-2, Bcl-xl, sialyl transferase inhibitor.

Product Type:

Biochemicals

CAS Number:

12542-36-8

Alternative Names:

2,2'-bis(8-Formyl-1,6,7-trihydroxy-5-isopropyl-3-methylnaphthalene)-acetic acid

Storage Temp:

4°C

Compound Purity:

≥98%

Molecular Weight:

578.61

Reference:

Deng S, Yuan H, Yi J, et al. Gossypol acetic acid induces apoptosis in RAW264.7 cells via a caspase-dependent mitochondrial signaling pathway. J Vet Sci. 2013;14(3):281-9. PMID: 23820203. Hall C, Troutman SM, Price DK, et al. Bcl-2 family of proteins as therapeutic targets in genitourinary neoplasms. Clin Genitourin Cancer. 2013 Mar;11(1):10-9. PMID: 23083798. Kisim A, Atmaca H, Cakar B, et al. Pretreatment with AT-101 enhances tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis of breast cancer cells by inducing death receptors 4 and 5 protein levels. J Cancer Res Clin Oncol. 2012 Jul;138(7):1155-63. PMID: 22411600. El-Sharaky AS, Wahby MM, Bader El-Dein MM, et al. Mutual anti-oxidative effect of gossypol acetic acid and gossypol-iron complex on hepatic lipid peroxidation in male rats. Food Chem Toxicol. 2009 Nov;47(11):2735-41. PMID: 19665044. Loberg RD, McGregor N, Ying C, et al. In vivo evaluation of AT-101 (R-(-)-gossypol acetic acid) in androgen-independent growth of VCaP prostate cancer cells in combination with surgical castration. Neoplasia. 2007 Dec;9(12):1030-7. PMID: 18084610. Yildirim-Aksoy M, Lim C, Dowd MK, et al. In vitro inhibitory effect of gossypol from gossypol-acetic acid, and (+)- and (-)-isomers of gossypol on the growth of Edwardsiella ictaluri. J Appl Microbiol. 2004;97(1):87-92. PMID: 15186445. Sharma S, Kumar M, Goyal RB, et al. Reversible antispermatogenic effect of gossypol in langur monkeys (Presbytis entellus entellus). Adv Contracept. 1999;15(1):15-27. PMID: 10794043. Teng CS. Reversible changes in the content of cellular and microtubular tubulin in spermatogenic cells after gossypol treatment. Contraception. 1997 Jan;55(1):41-6. PMID: 9013060. Levinsky H, Singer R, Sagiv M, et al. Inhibition of sialyl transferase activity by gossypol acetic acid in human seminal plasma. Andrologia. 1991 Mar-Apr;23(2):159-61. PMID: 1952122.

Structure:

C30H30O8 C2H4O2

Formula:

C30H30O8 C2H4O2

UNSPSC Code:

12352200

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