Triptolide
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38748-32-2
≥98%
A crystalline solid
C20H24O6
360.4
3bs,4,4as,6r,6ar,7as,7bs,8bs,9,10-
- MSDS: View or download
A diterpenoid triepoxide with diverse biological activities; inhibits dCTP pyrophosphatase 1 (Ki = 168 µM); reduces viability of A549, H1299, NCI H520, NCI H1650, and H1975 human NSCLC cells at 50 nM; intranasal administration of liposomes containing triptolide (0.4 mg/kg) reduces tumor growth in a rat orthotopic model of lung cancer; reduces intestinal inflammation and prevents colon shortening in a mouse model of DSS-induced colitis at 0.2 mg/kg; inhibits skin allograft rejection and increases graft survival time in mice at 0.1 mg/kg per day post-transplantation
