Ruxolitinib
Catalogue number:
CAY11609-10 mg
Supplier:
Size:
10 mg
Product is available in:
£159.00
Estimated delivery Wed 24 Dec
Shipping is calculated in checkout
Shipping is calculated in checkout
This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
941678-49-5
Purity:
≥98%
Formulation:
A crystalline solid
Molecular Formula:
C17H18N6
Molecular Weight:
306.4
Alternative Names:
βr-
Product Description:
A potent ATP mimetic that inhibits both JAK1 and JAK2 with IC50 values of 2.7 and 4.5 nM, respectively; blocks IL-6 signaling (IC50 = 281 nM) and proliferation of JAK2V617F+ Ba/F3 cells (IC50 = 127 nM); reduces splenomegaly, decreases circulating levels of IL-6 and TNF-α, eliminates neoplastic cells, and prolongs survival in a mouse model of JAK2V617F+ MPN
