Thapsigargin
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67526-95-8
≥97%
A crystalline solid
C34H50O12
650.8
(3s,3as,4r,6r,7s,8r)-
A SERCA inhibitor (IC50 = ~30 nM for the rat liver microsomal enzyme) and ER stress inducer; increases intracellular calcium levels in isolated rat hepatocytes (EC50 = ~80 nM) and protein levels of DDIT3, GRP78, as well as phosphorylation of PERK and eIF2α in SH-SY5Y cells at 1 µM; protects primary mouse BMDMs against TNF- and zVAD-induced necroptosis at 2 µg/ml for 1 h; induces apoptosis in SW-13 cells from 2-16 µM; induces autophagosome accumulation in MEFs at 3 µM; reduces viral titers in Vero E6 cells co-infected with SARS-CoV-2 and influenza A strain H1N1 at 0.5 µM; reduces tumor volume in an SW-13 mouse xenograft model 1 mg/kg
