NEK7 degrader-1
Catalogue number:
TYD-05040-10mg
Supplier:
Size:
10 mg
Product is available in:
CAS Number:
3069891-91-1
Purity:
≥95%
Molecular Formula:
C21H22Cl2N4O3
Molecular Weight:
449.33
- Data sheet: View or download
- MSDS: View or download
Product Description:
NEK7 degrader-1 is a NEK7 molecular glue degrader with a DC50 of 0.1 nM. NEK7 degrader-1 dose-dependently inhibits caspase-1 activity and IL-1β release in macrophages in response to NLRP3 inflammasome activation. NEK7 degrader-1 can be used for research on autoinflammatory and autoimmune diseases (e.g., multiple sclerosis), neurodegenerative diseases (e.g., Alzheimer's disease), and cardiovascular and pigmentation disorders (e.g., pericarditis and type 2 diabetes).