Histone H3 (1-24) K9(Ac)

This Histone 3 peptide is acetylated at lysine residue at 9th position. In a glioblastoma xenograft expressing a O6-methylguanine-DNA methyltransferase (MGMT), increased H3K9-ac was observed in correlation to histone acetylation and MGMT upregulation, thus demonstrating a mechanism driven by chromatin-mediated MGMT upregulation in potentially directing epigenetic therapies to influence the mechanisms of resistance development in glioblastomas.