SPP 86
Catalogue number:
CAY37390-1 mg
Supplier:
Size:
1 mg
Product is available in:
£32.00
Estimated delivery Mon 20 Oct
Shipping is calculated in checkout
Shipping is calculated in checkout
This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
1357349-91-7
Purity:
≥98%
Formulation:
A solid
Molecular Formula:
C16H15N5
Molecular Weight:
277.324
Alternative Names:
1-(1-methylethyl)-3-(2-phenylethynyl)-1h-pyrazolo[3,4-d]pyrimidin-4-amine
Product Description:
A RET inhibitor (IC50 = 0.008 µM); selective for RET over a panel of 44 serine/threonine/tyrosine kinases at 10 µM but does inhibit nine by >75%; selective for RET over a panel of 63 receptor and non-receptor tyrosine kinases 0.4 µM but does inhibit six, including RET, by >75%; reduces the proliferation of HCT116 and TPC-1 cells (EC50s = 2.4 and 3.3 µM, respectively); inhibits viral replication in FMDV-infected BHK-21 cells at 5 µM