YKL-5-124
Catalogue number:
CAY31057-1 mg
Supplier:
Size:
1 mg
Product is available in:
£36.00
Estimated delivery Wed 15 Apr
Shipping is calculated in checkout
Shipping is calculated in checkout
This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
1957203-01-8
Purity:
≥90%
Formulation:
A solid
Molecular Formula:
C28H33N7O3
Molecular Weight:
515.607
Alternative Names:
n-[(1s)-2-(di
Product Description:
A Cdk7 inhibitor (IC50 = 9.7 nM); selective for Cdk7 over Cdk2 and Cdk9 (IC50s = 1,300 and 3,020 nM, respectively); induces cell cycle arrest at G1 and G2 phases in HAP1 cells at 60 nM; inhibits HIV-1 provirus expression in HIV-1-infected J-Lat 10.6 cells at 100 nM; decreases tumor volume and increases survival in combination with JQ1 in a PDX mouse model of neuroblastoma at 2.5 mg/kg per day