QC6352
Catalogue number:
CAY26231-1 mg
Supplier:
Size:
1 mg
Product is available in:
£175.00
Estimated delivery Mon 12 Jan
Shipping is calculated in checkout
Shipping is calculated in checkout
This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
1851373-36-8
Purity:
≥98%
Formulation:
A solid
Molecular Formula:
C24H25N3O2
Molecular Weight:
387.47432
Alternative Names:
3-[[[(1r)-
Product Description:
A KDM4 inhibitor; selective for KDM4A, KDM4B, KDM4C, and KDM4D (IC50s = 104, 56, 35, and 104 nM, respectively) over KDM2B, KDM3A, KDM3B, KDM6B, and PHF8 (IC50s = >4,000 nM for all) but does inhibit KDM5B (IC50 = 750 nM); increases H3K36Me3 levels in KYSE-150 cells (EC50 = 1.3 nM); reduces the proliferation of KYSE-150 cells (EC50 = 3.5 nM) but not IMR-90 fibroblasts (IC50 = >30 µM); reduces tumor volume in a BR0859f PDX mouse model of HER2-positive breast cancer at 10, 25, and 50 mg/kg