AU-15330
Catalogue number:
CAY43318-1 mg
Supplier:
Size:
1 mg
Product is available in:
£83.00
Estimated delivery Wed 15 Apr
Shipping is calculated in checkout
Shipping is calculated in checkout
This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
2380274-50-8
Purity:
≥98%
Formulation:
A solid
Molecular Formula:
C39H49N9O5S
Molecular Weight:
755.939
Alternative Names:
(2s,4r)-1-
Product Description:
A PROTAC that drives BRM and BRG1 degradation; induces degradation of BRM and BRG1 in HeLa cervical cancer cells at 1 µM but also induces degradation of PBRM1 at the same concentration; decreases proliferation in a panel of 14 cancer cell lines (IC50s = 0.392-28.85 nM); reduces protein levels of FOXA1, ERG, Myc, and prostate-specific antigen in VCaP cells at 1 µM for 24 hours; reduces tumor volume in a VCaP mouse xenograft model