£387.00
Estimated delivery Fri 26 Sep
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This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
1134334-55-6
Purity:
≥95%
Formulation:
A solid
Molecular Formula:
C12H10ClN3O
Molecular Weight:
247.68012
Alternative Names:
4-chloro-8-methoxy-5-methyl-5h-pyrimido[5,4-b]indole
Product Description:
A PRMT9 inhibitor (IC50 = 0.9 µM); reduces the proliferation of Rec-1, Raji, UPN1, BL-41, and OCI-Ly3 cells (IC50s = 2.5-5 µM); induces cell cycle arrest at the G2/M phase in THP-1 cells at 2.5 µM; decreases phosphorylated levels of Chk1 and Chk2 in THP-1 cells; decreases tumor volume in combination with an anti-PD-1 antibody in an AML mouse xenograft model at 10 mg/kg twice per day