AMG-1694
Catalogue number:
T14212-200 mg
Supplier:
Size:
200 mg
Product is available in:
CAS Number:
1361217-07-3
Purity:
≥95%
Molecular Formula:
C23H30F3N3O4S2
Molecular Weight:
533.63
- Data sheet: View or download
- MSDS: View or download
Product Description:
AMG-1694, a potent disruptor of the glucokinase–glucokinase regulatory protein (GK-GKRP) complex, operates by promoting the dissociation of this complex, thereby indirectly enhancing GK enzymatic activity with an IC50 of 7 nM. It effectively normalizes blood glucose levels in various rodent diabetes models [1] and lowers blood glucose specifically in diabetic animals without affecting normoglycemic ones. Additionally, AMG-1694 reverses the GKRP-induced inhibition of GK activity and facilitates GK translocation.