GED-0507-34 Levo
Catalogue number:
T202784-200 mg
Supplier:
Size:
200 mg
Product is available in:
CAS Number:
921195-93-9
Alternative Names:
(S)-3-(4-Aminophenyl)-2-methoxypropanoicacid , Y4H78S56YZ , (S)-3-(4-Aminophenyl)-2-methoxypropanoic acid
Product Description:
GED-0507-34 Levo ((S)-3-(4-Aminophenyl)-2-methoxypropanoic acid), an orally available PPARγ modulator for amelioration of inflammation-driven intestinal fibrosis, decreased the expression of the pro-fibrotic genes Acta2, COL1a1, and Fn1, reduced the protein levels of α-SMA and collagen I-II, the main markers of fibrosis, as well as the major components of the TGFβ/Smad pathway, and decreased the expression of IL-13, CTGF, TGFB and ACTA1, and inhibited TGF-β-induced activation of fibroblasts and IECs cell lines.