GLPG2534
Catalogue number:
CAY42048-10 mg
Supplier:
Size:
10 mg
Product is available in:
£658.00
Estimated delivery Wed 24 Dec
Shipping is calculated in checkout
Shipping is calculated in checkout
This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
2095615-97-5
Purity:
≥98%
Formulation:
A solid
Molecular Formula:
C21H24N6O4
Molecular Weight:
424.4533
Alternative Names:
6-[6-[2-(2-
Product Description:
An IRAK4 inhibitor (IC50s = 6.4 and 3.5 nM for the human and mouse enzymes, respectively); selective for IRAK4 over IRAK1 (IC50 = 179 nM) and a panel of 151 additional kinases at 1 µM but does inhibit FLT3, TrkB, and VEGFR3 (IC50s = 2.2, 5.8, and 57 nM, respectively); inhibits CL097-induced TNF-α release in isolated human PBMCs and human whole blood (IC50s = 122.8 and 568 nM, respectively); reduces ear thickness in mouse models of psoriasis induced by recombinant mouse IL-23 or imiquimod and mouse models of atopic dermatitis induced by recombinant mouse IL-33 or MC903