£42.00
Estimated delivery Wed 24 Dec
Shipping is calculated in checkout
Shipping is calculated in checkout
This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
1030203-81-6
Purity:
≥98%
Formulation:
A solid
Molecular Formula:
C14H12ClN5O2S
Molecular Weight:
349.8
Alternative Names:
2-[[1-(3-
Product Description:
A DAPK1 (IC50 = 200 nM) and DAPK3 inhibitor; selectively binds to DAPK1, DAPK2, and DAPK3 (Kds = 300, 79, and 280 nM, respectively) over Pim-1, Pim-2, and Pim-3 (Kds = 1,800, 6,500, and 810 nM, respectively) but does inhibit Pim-3 (IC50 = 200 nM); inhibits phosphorylation of RLC20 in primary human coronary artery smooth muscle cells at 10 µM; reduces phenylephrine-induced contractions in isolated mouse aortic rings and increases the time to reach 50% maximal contractions in calyculin A-stimulated isolated rat caudal arterial smooth muscle strips at 10 and 100 µM, respectively