Z-FA-FMK
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96922-64-4
[2-[(3-fluoro-1-methyl-2-oxopropyl)amino]-2-oxo-1-(phenylmethyl)ethyl]-carbamic acid, phenylmethyl ester, cathepsin b inhibitor, z-phe-ala-fluoromethyl ketone
A cathepsin B inhibitor (Ki = 1.5 µM); inhibits caspase-2, -3, -6, -7, and -9 (IC50 = 6.147, 15.410, 32.45, 9.077, and 110.7 µM, respectively); inhibits SARS-CoV-2 Mpro in a cell-free assay (IC50 = 11.39 µM); inhibits SARS-CoV-2 replication in infected Vero E6 cells (EC50 = 0.13 µM) without inducing cytotoxicity in the same cells (CC50 = >20 µM); decreases the proliferation of, and levels of GSH in, and increases levels of ROS in anti-CD3-stimulated primary human PBMCs at 50 µM; inhibits LPS-induced increases in levels of IL-1β in PU5-1.8 macrophages and Nf-κB transactivation in Mf4/4 macrophages at 50 µM