Human HAVCR2 Antibody Pair
Hepatitis A virus cellular receptor 2, HAVcr-2, T-cell immunoglobulin and mucin domain-containing protein 3, TIMD-3, T-cell immunoglobulin mucin receptor 3, TIM-3, T-cell membrane protein 3, CD antigen CD366
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Hepatitis A virus cellular receptor 2 (HAVCR2), also known as T-cell immunoglobulin mucin 3 (TIM-3), is a protein encoded by the HAVCR2 gene located on chromosome 5. This receptor is part of the immunoglobulin superfamily and plays a crucial role in regulating immune responses, particularly in T-helper type 1 (Th1) cells, where it inhibits Th1-mediated autoimmune responses and promotes immunological tolerance. HAVCR2 has been implicated in various diseases, including subcutaneous panniculitis-like T-cell lymphoma and hepatitis A, and is recognized as a potential target for immunotherapy due to its involvement in tumor immunity and prognosis across multiple cancer types. Research indicates that HAVCR2 expression levels correlate with immune infiltration in tumors, suggesting its dual role as both an immune checkpoint and a biomarker for therapeutic strategies in cancer treatment. Capture antibody: 100 µg. Detection antibody: 100 µg