Human STAMBP Antibody Pair

• Data sheet: View or download

STAM-binding protein (STAMBP), also known as AMSH, is a deubiquitinating enzyme that plays a vital role in endosomal sorting and trafficking. It interacts with endosomal sorting complexes required for transport (ESCRTs), facilitating the removal of ubiquitin from target proteins, which is essential for maintaining protein homeostasis within cells. STAMBP's functions extend beyond protein degradation; it is involved in various signaling pathways, including those related to cell growth and angiogenesis. Dysregulation of STAMBP has been linked to several diseases. Notably, mutations in the STAMBP gene are associated with microcephaly-capillary malformation syndrome, characterized by developmental delays, seizures, and vascular abnormalities due to impaired protein degradation and signaling. Additionally, STAMBP has been implicated in cancer progression, particularly in triple-negative breast cancer (TNBC), where it promotes tumor growth by stabilizing the actin-binding protein RAI14 through deubiquitination. Capture antibody: 100 µg. Detection antibody: 100 µg