Human SARNP Antibody Pair
SAP domain-containing ribonucleoprotein, Cytokine-induced protein of 29 kDa, Nuclear protein Hcc-1, Proliferation-associated cytokine-inducible protein CIP29
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SAP domain containing ribonucleoprotein (SARNP) is a protein characterized by its N-terminal SAP domain, which is implicated in DNA binding and RNA processing. This protein plays a crucial role in the assembly and export of messenger ribonucleoprotein (mRNP) complexes, particularly through its interactions with other proteins like DDX39B, facilitating the formation of multimers on RNA for efficient mRNP packaging. The protein exhibits intrinsic RNA-binding capabilities and can bind both single-stranded and double-stranded DNA, with a preference for single-stranded forms, highlighting its multifaceted role in nucleic acid interactions. SARNP has been linked to several diseases, notably cancer, where its upregulation in response to cytokines suggests a role in cell cycle progression and tumorigenesis. Additionally, alterations in SARNP expression may influence the pathophysiology of neurodegenerative conditions due to its involvement in RNA metabolism and cellular stress responses.