(E)-5-(2-Bromovinyl)uracil
Catalogue number:
T35439-100 mg
Supplier:
Size:
100 mg
Product is available in:
CAS Number:
69304-49-0
Molecular Formula:
C6H5BrN2O2
Molecular Weight:
217.02
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- MSDS: View or download
Product Description:
(E)-5-(2-Bromovinyl)uracil (BVU) is a pyrimidine base and an inactive metabolite of the antiviral agents sorivudine and (E)-5-(2-bromovinyl)-2'-deoxyuridine (BVDU), which can be regenerated to BVDU in vivo. BVU irreversibly inactivates dihydropyrimidine dehydrogenase (DPD) in an NADPH-dependent manner, enhancing the efficacy of the chemotherapeutic agent and DPD substrate 5-fluorouracil in a P388 murine leukemia model when administered at a dose of 200 µmol/kg, thereby increasing survival time.