Buclizine dihydrochloride
Catalogue number:
T6426-50 mg
Supplier:
Size:
50 mg
Product is available in:
CAS Number:
129-74-8
Purity:
≥98%
Molecular Formula:
C28H33ClN2·2HCl
Molecular Weight:
505.95
Alternative Names:
Longifene , Buclina , Buclizine HCl , UCB-4445
- Data sheet: View or download
- MSDS: View or download
Product Description:
Buclizine dihydrochloride (Buclina) is the hydrochloride salt form of buclizine, a piperazine histamine H1 receptor antagonist with primarily antiemetic and antivertigo activities. Buclizine dihydrochloride binds to and blocks the histamine H1 receptor, thereby preventing the symptoms that are caused by histamine activity. Buclizine dihydrochloride exerts its anti-emetic effect by binding to and blocking the muscarinic and histamine receptors in the vomiting center of the central nervous system (CNS). This may prevent activation of the chemoreceptor trigger zone (CTZ) and may reduce nausea and vomiting.