Avapritinib
Catalogue number:
T5109-25 mg
Supplier:
Size:
25 mg
Product is available in:
CAS Number:
1703793-34-3
Purity:
≥95%
Molecular Formula:
C26H27FN10
Molecular Weight:
498.56
Alternative Names:
BLU-285
- Data sheet: View or download
- MSDS: View or download
- Protocol: View or download
Product Description:
Avapritinib (BLU-285) is a selective, highly potent, and orally active inhibitor of KIT and PDGFRA activation loop mutant kinases, targeting KIT D816V (IC50:0.27 nM) and PDGFRA D842V (IC50:0.24 nM), and attenuates the transport functions of ABCB1 and ABCG2. It binds to the active conformation of the kinases and exhibits antitumor activity.