K-604 (hydrochloride)

An ACAT-1 inhibitor (IC50 = 0.45 µM); selective for ACAT-1 over ACAT-2 (IC50 = 102.85 µM); reduces cholesterol esterification in monocyte-derived macrophages (IC50 = 0.068 µM); decreases lipid-accumulation areas in the aortic arch in atherosclerosis-susceptible Bio F1B hamsters fed a high-fat and high-cholesterol diet at 10 mg/kg and reduces plasma total cholesterol levels in the same model at 10 and 30 mg/kg; increases autophagosome formation in N2a cells at 0.1 and 1 µM; decreases wild-type and mutant P301L-tau levels in N2a cells overexpressing these proteins but does not affect endogenous tau levels; intranasal administration reduces the level of brain cholesteryl esters in mice at 105 µg/animal