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RP 6306

Catalogue number:
CAY41732-50 mg
Supplier:
Size:
50 mg
Product is available in:
  • UK
  • Ireland
  • Europe
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  • Rest of World
£992.00 Estimated delivery Wed 15 Apr
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This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:

2719793-90-3

Purity:

≥95%

Formulation:

A solid

Molecular Formula:

C18H20N4O2

Molecular Weight:

324.37716

Alternative Names:

(1s)-2-amino-1-(3-hydroxy-2,6-dimethylphenyl)-5,6-dimethyl-1h-pyrrolo[2,3-b]pyridine-3-carboxamide, (s)-rp 6306, lunresertib

Product Description:

An Myt1 kinase inhibitor (IC50 = 0.002 nM in a BRET assay); greater than 29-fold selective for Myt1 kinase over eight other kinases in BRET assays at 1.2 µM; increases the levels of DNA-associated γH2AX in hTERT FT 282 cells at 500 nM; induces cell cycle arrest at the S phase in hTERT FT 282 cells; reduces tumor volume in an OVCAR-3 ovarian cancer mouse xenograft model at 15, 50, or 300 ppm in the diet