Curzerene

A sesquiterpene with diverse biological activities; scavenges DPPH radicals in a cell-free assay at 3.36 µg/L with a synergistic effect when used in combination with eucalyptol; active against F. graminearum at 0.5 mg/ml; inhibits the proliferation of SK-MEL-19 melanoma cells (IC50 = 5.17 µg/ml), as well as AGP-01 gastric and HCT116 colon cancer cells (IC50s = 8.04 and 9.18 µg/ml, respectively) and MRC-5 non-cancerous human fibroblasts (IC50 = 11.45 µg/ml); induces apoptosis in, and decreases migration of, SK-MEL-19 cells at 5 and 10 µM; reduces tumor weight in an SPC-A1 mouse xenograft model at 135 mg/kg