Delta-AITX-Avd1c Protein, Anemonia sulcata, Recombinant (His)
Catalogue number:
TMPH-00056-1 mg
Supplier:
Size:
1 mg
Product is available in:
Molecular Weight:
6.9
Alternative Names:
Neurotoxin 2 , Toxin II , Anemonia sulcata toxin 2 (As2) , Delta-actitoxin-Avd1c , ATX-II (ATX II) , Delta-AITX-Avd1c
- Data sheet: View or download
- MSDS: View or download
Product Description:
Binds specifically to voltage-gated sodium channels (Nav) (site 3), thereby delaying their inactivation. Has a strong effect on crustaceans and insects (DmNav1) and a weaker effect on mammals. This toxin is highly potent at mammalian Nav1.1/SCN1A (EC(50)=6.01 nM) and Nav1.2/SCN2A (EC(50)=7.88 nM). It has also great activity on Nav1.5/SCN5A (EC(50)=49.05 nM), Nav1.4/SCN4A (EC(50)=109.49 nM) and Nav1.6/SCN8A (EC(50)=about 180 nM) and is less potent on Nav1.3/SCN3A (EC(50)=759.22 nM) (when measured as the increase in the slow component).
