AS-99
Catalogue number:
T73529-50 mg
Supplier:
Size:
50 mg
Product is available in:
Molecular Formula:
C27H31ClF3N5O3S2
Molecular Weight:
630.14
- Data sheet: View or download
- MSDS: View or download
Product Description:
AS-99 is a first-in-class, potent, and selective inhibitor of the ASH1L histone methyltransferase, displaying anti-leukemic activity with an IC50 of 0.79 µM and a Kd of 0.89 µM. It inhibits cell proliferation, induces apoptosis and differentiation, downregulates MLL fusion target genes, and effectively reduces leukemia burden [in vivo].
