SMTIN-T140
Catalogue number:
T73125-50 mg
Supplier:
Size:
50 mg
Product is available in:
CAS Number:
2851532-40-4
Molecular Formula:
C36H34BrClFN5OP+
Molecular Weight:
718.02
- Data sheet: View or download
- MSDS: View or download
Product Description:
SMTIN-T140 (compound 6a), a potent TRAP1 (tumor-necrosis-factor-receptor associated protein 1) inhibitor with an IC50 of 1.646 µM, exhibits anticancer activity by inducing mitochondrial dysfunction, elevating mitochondrial ROS production, and activating AMPK. Notably, SMTIN-T140 effectively suppressed tumor growth without discernible in vivo toxicity in a PC3 prostate cancer cell-xenografted mouse model [1].
