DBPR112 HCl
Catalogue number:
T69498-25 mg
Supplier:
Size:
25 mg
Product is available in:
CAS Number:
2889316-21-4
Molecular Formula:
C32H32ClN5O3
Molecular Weight:
570.08
- Data sheet: View or download
- MSDS: View or download
Product Description:
DBPR112 is a potent EGFR inhibitor (IC50=487 nM) as a Clinical Candidate for the Treatment of Non-Small Cell Lung Cancer. DBPR112), DBPR112 not only displayed a potent inhibitory activity against EGFRL858R/T790M double mutations but also exhibited tenfold potency better than the third-generation inhibitor, osimertinib,against EGFR and HER2 exon 20 insertion mutations. Overall, pharmacokinetic improvement through lead-to-candidate optimization yielded fourfold oral AUC better that afatinib along with F = 41.5%, an encouraging safety profile, and significant antitumor efficacy in in vivo xenograft models.
