XL-418
Catalogue number:
T68477-50 mg
Supplier:
Size:
50 mg
Product is available in:
CAS Number:
871343-09-8
Molecular Formula:
C26H32BrF3N8O
Molecular Weight:
609.48
- Data sheet: View or download
- MSDS: View or download
- Protocol: View or download
Product Description:
XL-418 is a selective, orally active small molecule, targeting protein kinase B (PKB or AKT) and ribosomal protein S6 Kinase (p70S6K), with potential antineoplastic activity. XL418 inhibits the activities of PKB and p70S6K, both acting downstream of phosphoinosotide-3 kinase (PI3K). These kinases are often upregulated in a variety of cancers. Inhibition of PKB by this agent will induce apoptosis, while inhibition of p70S6K will result in the inhibition of translation within tumor cells.
