AKI-001
Catalogue number:
T68332-100 mg
Supplier:
Size:
100 mg
Product is available in:
CAS Number:
925218-37-7
Molecular Formula:
C21H24N4O
Molecular Weight:
348.44
- Data sheet: View or download
- MSDS: View or download
Product Description:
AKI-001 is a potent Aurora kinase inhibitor, which exhibits low nanomolar potency against both Aurora A and Aurora B enzymes, excellent cellular potency (IC50 < 100 nM), and good oral bioavailability. Phenotypic cellular assays show that both Aurora A and Aurora B are inhibited at inhibitor concentrations sufficient to block proliferation. Importantly, the cellular activity translates to potent inhibition of tumor growth in vivo. An oral dose of 5 mg/kg QD is well tolerated and results in near stasis (92% TGI) in an HCT116 mouse xenograft model.
