HPI-1 (hydrate)
Catalogue number:
T35538-25 mg
Supplier:
Size:
25 mg
Product is available in:
CAS Number:
1262770-72-8
Molecular Formula:
C27H31NO7
Molecular Weight:
481.54
Alternative Names:
HPI-1 hydrate
- Data sheet: View or download
- MSDS: View or download
Product Description:
HPI-1 (hydrate) is a Hedgehog (Hh) pathway inhibitor that suppresses signaling through Sonic Hh (IC50= 1.5 µM) without significantly affecting Wnt signaling (IC50≥ 30 µM).1HPI-1 suppresses Hh activation induced by loss of Suppressor of Fused or by Gli overexpression, suggesting action at posttranslational modification of Gli protein or at the interaction of Gli with a co-factor.1HPI-1 (hydrate) also inhibits signaling through the oncogenic Smoothened (Smo) mutant SmoM2 in neuron precursors, preventing cell proliferation.1
