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CAS Number:
1817791-73-3
Molecular Formula:
C33H39N7O2
Molecular Weight:
565.71
Alternative Names:
NTRC00660, NTRC-0066-0, NTRC-00660, NTRC0066-0
- Data sheet: View or download
Product Description:
NTRC-0066-0 is a a highly potent and selective inhibitor of TTK. NTRC 0066-0 inhibits the phosphorylation of a TTK substrate and induces chromosome missegregation. NTRC 0066-0 inhibits tumor growth in MDA-MB-231 xenografts as a single agent after oral application. The combination of NTRC 0066-0 with a therapeutic dose of docetaxel resulted in doubling of mouse survival and extended tumor remission, without toxicity.