(S,R,S)-AHPC-Me dihydrochloride
Catalogue number:
T13671L-5 mg
Supplier:
Size:
5 mg
Product is available in:
Molecular Formula:
C23H34Cl2N4O3S
Molecular Weight:
517.51
Alternative Names:
VHL ligand 2 dihydrochloride , E3 ligase Ligand 1 dihydrochloride , (S,R,S)-AHPC-Me dihydrochloride (1948273-02-6 free base)
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- MSDS: View or download
Product Description:
(S,R,S)-AHPC-Me dihydrochloride, also known as VHL ligand 2 dihydrochloride, is a chemical compound used in the synthesis of ARV-771. ARV-771 is a BET PROTAC degrader that relies on von Hippel-Landau (VHL) E3 ligase and exhibits potent degradation of BET proteins in castration-resistant prostate cancer (CRPC) cells, with a DC50 of less than 1 nM. This compound acts as the VHL ligand, specifically the (S,R,S)-AHPC-based VHL ligand, facilitating the recruitment of von Hippel-Lindau (VHL) protein.