JHU395
Catalogue number:
T11717-1 mg
Supplier:
Size:
1 mg
Product is available in:
CAS Number:
2079938-92-2
Purity:
≥98%
Molecular Formula:
C22H29N3O7
Molecular Weight:
447.48
- Data sheet: View or download
- MSDS: View or download
Product Description:
JHU395 is an orally-bioavailable prodrug of a lipophilic glutamine antagonist (GA), 6-diazo-5-oxo-L-norleucine (DON). It demonstrates delivery of DON to malignant peripheral nerve sheath tumor (MPNST) both in vitro and in vivo, resulting in significant antitumor activity in MPNST. Additionally, JHU395 exhibits plasma stability.
