MK-8719

An OGA inhibitor (Ki = 7.9 nM for the human enzyme); selective for OGA over β-hexosaminidase (Ki = >10,000 nM for the human enzyme); increases the levels of O-GlcNAcylated proteins in rat PC12 cells (EC50 = 52.7 nM); increases brain levels of O-GlcNAcylated proteins in rats at 10 mg/kg; reduces the levels of aggregated tau proteins in the brain, the levels of neurofibril tangles in the entorhinal cortex, and spontaneous locomotor activity, as well as increases cortex, hippocampal, and lateral ventricular volume and forebrain weight, in an rTg4510 transgenic mouse model of Alzheimer's disease when administered in the diet