IL-6 Responsive Luciferase Reporter HEK293 Cell Line
Catalogue number:
BPS-82235
Supplier:
Size:
2 vials
Product is available in:
Alternative Names:
IL-27 responsive cell line, C P690,550 responsive cell line, anti-IL-6R antibody responsive cell line
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Product Description:
IL-6 Responsive Luciferase Reporter HEK293 Cell Line is a HEK293 cell line designed to monitor the IL-6 (interleukin 6)/IL-6 receptor interaction. These cells express endogenous IL-6 receptor (IL-6R and gp130) and were engineered to express firefly luciferase under the control of a STAT response element. This cell line has been validated to respond to human interleukin-6 (IL-6), IL-27, and further functional validation experiments showed that IL-6-induced luciferase activity was decreased by the JAK inhibitor CP 690,550 and by an anti-IL-6R neutralizing antibody.