Ionizable Lipid 4

Name: Ionizable Lipid 4
Brand: Cayman Chemical
SKU: CBSKU_201457563
Price: 126 GBP
Availability: InStock

Catalogue number:

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CAY40496-5 mg

Supplier:

Cayman Chemical

Size:

5 mg

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£126.00

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Estimated delivery Wed 24 Dec
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This product is for research use only and is not for human consumption or therapeutic use.

CAS Number:

1799316-81-6

Purity:

≥95%

Formulation:

A solution in methyl acetate

Molecular Formula:

C48H85NO7

Molecular Weight:

788.19104

Alternative Names:

9,12-octadecadienoic acid, (9z,12z)-1,1′-[2-[[[[3-(diethylamino)propoxy]carbonyl]oxy]methyl]-1,3-propanediyl] ester

Product Description:

An ionizable cationic lipid (pKa = 6.1) and hydrogen peroxide-induced rearrangement product of the cationic lipid CA-lipid 5; CALNPs containing CA-lipid 5 and encapsulating siRNA against EGFP undergo hydrogen peroxide-induced removal of the phenylboronic acid groups from CA-lipid 5 in MCF-7 cells in vitro, generating ionizable lipid 4-containing LNPs with reduced positive charges at physiological pH, facilitating intracellular siRNA release and gene silencing; LNPs containing ionizable lipid 4 and encapsulating siRNA against PLK1 reduce tumor volume in an MCF-7 mouse xenograft model