PE 22-28 (acetate)

A peptide inhibitor of K2P2.1/TREK1 (IC50 = 0.1 nM in HEK293 cells expressing the human channel); selective for K2P2.1/TREK1 over K2P10.1 /TREK2, K2P13.1/TRAAK, K2P18.1/TRESK, and K2P3.1/TASK1 in HEK293 cells expressing the human channels at 100 nM; increases neurogenesis and the levels of Psd-95, a measure of increased synaptogenesis, in isolated mouse hippocampi at 4 µg/kg for four days; decreases immobility in the forced swim test, latency to feed in the novelty-suppressed feeding test, and the time to escape in the Porsolt learned helplessness test in mice at 0.3 µg/kg for four days