KB-0742 (hydrochloride)
Catalogue number:
CAY39772-10 mg
Supplier:
Size:
10 mg
Product is available in:
£240.00
Estimated delivery Wed 15 Apr
Shipping is calculated in checkout
Shipping is calculated in checkout
This product is for research use only and is not for human consumption or therapeutic use.
Purity:
≥95%
Formulation:
A solid
Molecular Formula:
C16H25N5 • HCl
Molecular Weight:
323.86404
Alternative Names:
(1s,3s)-
Product Description:
A Cdk9 inhibitor (IC50 = 6 nM); selective for Cdk9 over Cdk1-8 (IC50s = 397->10,000 nM) and Cdk12-19 (IC50s = 372->10,000 nM); induces cell cycle arrest at the G1 phase and apoptosis in BT-20, BT-549, MDA-MB-231, MT-3, and Hs 578T TNBC cells from 0.64-7.73 µM; reduces tumor volume in the MYC-amplified CTG-0437 PDX mouse model of TNBC at 60 mg/kg