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ML-241 (hydrochloride)

Catalogue number:
CAY40400-10 mg
Supplier:
Size:
10 mg
Product is available in:
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£99.00 Estimated delivery Wed 17 Dec
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This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:

2070015-13-1

Purity:

≥98%

Formulation:

A solid

Molecular Formula:

C23H24N4O • HCl

Molecular Weight:

408.9

Alternative Names:

2-(2,3-dihydro-4h-1,4-benzoxazin-4-yl)-5,6,7,8-tetrahydro-n-(phenylmethyl)-4-quinazolinamine, monohydrochloride

Product Description:

A selective inhibitor of p97 (IC50 = 0.11 µM); selective for the p97 D2 domain; disrupts the ERAD pathway, preventing the degradation of p97-dependent proteasome substrates in a reporter assay using HeLa cells (IC50 = 3.5 µM) and inducing the accumulation of ubiquitin conjugates in the nuclear plus membrane and cytosolic compartments of SW403 cells at 5 and 10 µM